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2975-00-0

2975-00-0 structure
2975-00-0 structure

Name 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine,hydrochloride
Synonyms Altretamine hydrochloride
1,3,5-Triazine-2,4,6-triamine,N,N,N',N',N'',N''-hexamethyl-,monohydrochloride
2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine hydrochloride
Hexamethylmelamine HCl
Altretamine (hydrochloride)
Description Altretamine hydrochloride is an alkylating antineoplastic agent.
Related Catalog
In Vitro Altretamine hydrochloride is an antineoplastic agent[1].
In Vivo Altretamine (100, 133 mg/kg, ip.) in combination with Irofulven, increases the antitumor effect in mice bearing MV522 cells[1].
Animal Admin Mice[1] Balb/c nu/nu 4 week old female mice weighing 18-22 g, receive s.c. injections of 8-10 million MV522 cells. Altretamine is administered i.p. three times a week for 3 weeks, starting on day 10 after tumor implantation. Tumor size is measured in two perpendicular diameters and tumor weight (TW) estimated according to the formula: w = [(width)2 × length/2]. Altretamine is prepared as stock solutions of 1-10 mg/mL in 40% DMSO/normal saline and diluted with 10% DMSO/normal saline as required[1].
References

[1]. Kelner MJ, et al. Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26.

Boiling Point 339.4ºC at 760mmHg
Molecular Formula C9H19ClN6
Molecular Weight 246.74000
Flash Point 159.1ºC
Exact Mass 246.13600
PSA 48.39000
LogP 0.87160
Vapour Pressure 9.2E-05mmHg at 25°C
Storage condition 2-8℃