936889-68-8
936889-68-8 structure
- Name: OXA-01
- Chemical Name: Cyclohexanecarboxylic acid, 4-[8-amino-1-(7-chloro-1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl]-, trans
- CAS Number: 936889-68-8
- Molecular Formula: C21H20ClN5O2
- Molecular Weight: 409.86900
- Create Date: 2016-05-02 09:44:38
- Modify Date: 2024-02-05 16:07:32
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OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC50 values of 29 nM and 7 nM, respectively[1].
| Name | Cyclohexanecarboxylic acid, 4-[8-amino-1-(7-chloro-1H-indol-2-yl)imidazo[1,5-a]pyrazin-3-yl]-, trans |
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| Description | OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC50 values of 29 nM and 7 nM, respectively[1]. |
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| Related Catalog | |
| In Vivo | OXA-01 demonstrated broad anti-tumor activity in several different human xenograft models of various histologies. Furthermore, in GEO and Colo-205 colon xenograft models, OXA-01 demonstrated 100% TGI, whilst rapamycin treatment resulted in only 75% and 53% TGI, respectively[1]. |
| References |
[1]. OXA-01 displays improved anti-tumor activity in comparison to Rapamycin. |
| Density | 1.61±0.1 g/cm3 (20 °C, 760 mmHg) |
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| Molecular Formula | C21H20ClN5O2 |
| Molecular Weight | 409.86900 |
| Exact Mass | 409.13100 |
| PSA | 109.30000 |
| LogP | 5.05280 |