Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Chlorogenic acid
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Chlorogenic acid
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Chlorogenic acid
Price: ￥1128.0/5g ￥268.0/1g ￥88.0/20mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 3-O-caffeoylquinic acid
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Chlorogenic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

327-97-9

327-97-9 structure

Name: Chlorogenic acid
Chemical Name: chlorogenic acid
CAS Number: 327-97-9
Molecular Formula: C₁₆H₁₈O₉
Molecular Weight: 354.309
Catalog: API Antipyretic analgesics Antipyretic and analgesic
Create Date: 2018-02-03 08:00:00
Modify Date: 2024-01-02 14:53:18
Chlorogenic acid is a major phenolic compound in coffee and tea. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.

Name	chlorogenic acid
Synonyms	Hlorogenic acid Chlorogenic Acid Hydrate Caffeoyl quinic acid Chlorogenate (1S,3R,4R,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid 3-Caffeoylquinate 5-caffeoylquinic acid 3-O-Caffeoylquinic acid 3-Caffeoylquinic acid CHLOROGENIC ACID Chlorogenic acid,predominantly trans,from coffee seeds 3-(3,4-Dihydroxycinnamoyl)quinic Acid Hydrate Heriguard EINECS 206-325-6 3-mono-O-caffeoylquinic acid MFCD00003862

Description	Chlorogenic acid is a major phenolic compound in coffee and tea. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Inflammation/Immunology Natural Products >> Phenylpropanoids
References	[1]. Park JJ, et al. Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway. Cell Oncol (Dordr). 2015 Jan 6. [2]. Park SH, et al. IRAK4 as a Molecular Target in the Amelioration of Innate Immunity-Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid. J Immunol. 2015 Feb 1;194(3):1122-30. [3]. Kang JW, et al. Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats. Biomol Ther (Seoul). 2014 Sep;22(5):420-5.

Density	1.7±0.1 g/cm3
Boiling Point	665.0±55.0 °C at 760 mmHg
Melting Point	210 °C (dec.)(lit.)
Molecular Formula	C₁₆H₁₈O₉
Molecular Weight	354.309
Flash Point	245.5±25.0 °C
Exact Mass	354.095093
PSA	164.75000
LogP	-0.36
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.690
Water Solubility	SOLUBLE IN HOT WATER

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU8480000

CHEMICAL NAME :: Cyclohexanecarboxylic acid, 3-((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)- 1,4,5-trihydroxy-, (1S-(1-alpha,3-beta,4-alpha,5-alpha))-

CAS REGISTRY NUMBER :: 327-97-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H18-O9

MOLECULAR WEIGHT :: 354.34

WISWESSER LINE NOTATION :: L6TJ AQ BQ EVQ EQ COV1U1R CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 40 mg/kg

SEX/DURATION :: female 5-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 250 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 111,209,1983

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R68
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GU8480000

82592-68-5

327-97-9

Literature: Tetrahedron Letters, , vol. 46, # 39 p. 6645 - 6649

202650-88-2

327-97-9

905-99-7

Literature: Journal of Mass Spectrometry, , vol. 31, # 6 p. 602 - 608

176798-26-8

327-97-9

Literature: Tetrahedron Letters, , vol. 46, # 39 p. 6645 - 6649

32719-11-2

327-97-9

Literature: Journal of Agricultural and Food Chemistry, , vol. 57, # 13 p. 5843 - 5852

Precursor 4
82592-68-5 202650-88-2 176798-26-8 32719-11-2
DownStream 8
32719-11-2 331-39-5 77-95-2 905-99-7
202650-88-2 14534-61-3 99-50-3 3843-74-1

1049703-62-9	327-97-9
25514-46-9	37123-66-3
6001-76-9	7509-32-2
2432-85-1	2432-81-7
2432-46-4	11043-91-7
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	1375289-11-4
849349-65-1	127437-46-1