102146-07-6

102146-07-6 structure

Name: DPCPX
Chemical Name: 8-Cyclopentyl-1,3-dipropylxanthine
CAS Number: 102146-07-6
Molecular Formula: C₁₆H₂₄N₄O₂
Molecular Weight: 304.38700
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-06-20 13:39:03
Modify Date: 2024-07-18 10:02:11
DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3].

Name	8-Cyclopentyl-1,3-dipropylxanthine
Synonyms	8-Cyclopentyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione 8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione MFCD00055117

Description	DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Ki: 0.46 nM (3H-CHA binding to A1 receptors in rat whole brain membranes); 340 nM (3H-NECA binding to A2 receptors in rat striatal membranes)[2].
In Vivo	DPCPX (PD 116948) ( 0.1, 0.3 and 1.0 mg/kg i.v. ) produces significant dose-related increases (P<0.05) in urine volume and in urinary sodium, potassium and chloride excretion[3].
References	[1]. S J Haleen, et al. PD 116,948, a Highly Selective A1 Adenosine Receptor Antagonist. Life Sci. 1987 Feb 9;40(6):555-61. [2]. R F Bruns, et al. Binding of the A1-selective Adenosine Antagonist 8-cyclopentyl-1,3-dipropylxanthine to Rat Brain Membranes. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63. [3]. POSTER COMMUNICATIONS Part II. Br J Pharmacol. 1989 Jul; 97(Suppl): 496P–535P.

Density	1.195g/cm3
Boiling Point	535.1ºC at 760mmHg
Melting Point	178°C
Molecular Formula	C₁₆H₂₄N₄O₂
Molecular Weight	304.38700
Flash Point	277.4ºC
Exact Mass	304.19000
PSA	72.68000
LogP	2.36390
Appearance	solid \| white
Vapour Pressure	1.59E-11mmHg at 25°C
Index of Refraction	1.564
Storage condition	Store at RT
Stability	Store tightly sealed at RT; Solutions at 4 deg C for several days
Water Solubility	DMSO: >10 mg/mL

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

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HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%