116700-36-8

116700-36-8 structure

Name: H-9 dihydrochloride
Chemical Name: h-9 dihydrochloride
CAS Number: 116700-36-8
Molecular Formula: C₁₁H₁₅Cl₂N₃O₂S
Molecular Weight: 324.227
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-12-25 11:28:46
Modify Date: 2024-01-11 11:30:29
H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines[1][2][3].

Name	h-9 dihydrochloride
Synonyms	N-(2-Aminoethyl)-5-isoquinolinesulfonamide dihydrochloride 5-Isoquinolinesulfonamide, N-(2-aminoethyl)-, hydrochloride (1:2) N-(2-Aminoethyl)isoquinoline-5-sulfonamide dihydrochloride MFCD00069286

Description	H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines[1][2][3].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vitro	H-9 Dihydrochloride significantly inhibits A431 cells[1]. H-9 Dihydrochloride inhibits more effectively cyclic nucleotide-dependent protein kinases than other kinases[1].
In Vivo	H-9 Dihydrochloride microperfusion (100 μM) prevents picrotoxin seizures in 50% of the animals and significantly reduced the mean number of seizures and mean seizure duration[2].
References	[1]. Ito M, et al. A potent inhibitor of protein kinase C inhibits natural killer activity. Int J Immunopharmacol. 1988;10(3):211-6. [2]. Vázquez-López A, et al. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochem Res. 2005 May;30(5):613-8. [3]. Wollina U, et al. Inhibition of signal transduction in EGF-dependent epithelial cell lines. Int J Mol Med. 2003 Oct;12(4):673-7.

Melting Point	250-255ºC dec.
Molecular Formula	C₁₁H₁₅Cl₂N₃O₂S
Molecular Weight	324.227
Exact Mass	323.026215
PSA	93.46000
LogP	4.24780
Storage condition	−20°C

Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
WGK Germany	3
HS Code	2935009090

84468-15-5

107-15-3

116700-36-8

Literature: Journal of Medicinal Chemistry, , vol. 32, # 1 p. 42 - 46

Precursor 2
84468-15-5 107-15-3
DownStream 1
92564-34-6

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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