74115-08-5

74115-08-5 structure

Name: SKF-83822
Chemical Name: 9-chloro-5-(3-methylphenyl)-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol,hydrobromide
CAS Number: 74115-08-5
Molecular Formula: C₂₀H₂₂ClNO₂
Molecular Weight: 343.85
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2016-12-09 02:02:55
Modify Date: 2024-02-01 10:33:55
SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase, but not PLC. SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia[1][2].

Name	9-chloro-5-(3-methylphenyl)-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol,hydrobromide

Description	SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase, but not PLC. SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Rat D1 Receptor
In Vivo	SKF 83822（25-100 μg/kg；皮下注射；在使用拮抗剂后单次给药）以剂量依赖的方式在大鼠体内产生强烈的旋转反应。SKF 83822 还刺激去神经纹状体中 IEG 产物 c-Fos、Fra2、Zif/268 和 Arc 的强烈表达[1]。 SKF 83822 在猴子中分别以 0.25 mg/kg 和 0.35 mg/kg 的中等和高剂量显示出显著效果。并且 SKF 83822（0.15-0.35 mg/kg；皮下注射；单剂量）诱导运动而不诱导运动障碍。SKF 83822 导致极度兴奋和运动激活的状态，没有刻板印象[2]。 Animal Model: Adult, male Sprague-Dawley derived rats[1] Dosage: 6.25 μg/kg, 25 μg/kg, 50 μg/kg, and 100 μg/kg; with or without 0.5 mg/kg antagonist SCH 23390. Administration: SC; single dose, 30 min after antagonist treatment. Result: Produced a strong rotational response at 50 μg/kg which was approximately midway between that produced by the 25 and 100 μg/kg doses in the first experiment. Could be inhibited by antagonist of dopamine D1 receptor, SCH 23390.
References	[1]. Wirtshafter D. Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822. Pharmacol Biochem Behav. 2007 Mar;86(3):505-10. [2]. Peacock L, et al. Aberrant behavioral effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions. Biol Psychiatry. 2001 Oct 1;50(7):501-9.

Molecular Formula	C₂₀H₂₂ClNO₂
Molecular Weight	343.85
Exact Mass	423.06000
PSA	43.70000
LogP	5.13160

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