- BioBioPha
- China
- Product Name: Nepodin
- Price: ￥1000.0/5mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Nepodin
- Price: ￥1600.0/5mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Nepodin
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Ethanone,1-(1,8-dihydroxy-3-methyl-2-naphthalenyl)-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
3785-24-8
3785-24-8 structure
- Name: Nepodin
- Chemical Name: 1-(1,8-dihydroxy-3-methylnaphthalen-2-yl)ethanone
- CAS Number: 3785-24-8
- Molecular Formula: C13H12O3
- Molecular Weight: 216.233
- Catalog: Biochemical Chinese herbal medicine ingredients
- Create Date: 2018-04-10 08:00:00
- Modify Date: 2024-01-10 14:22:09
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Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.
| Name | 1-(1,8-dihydroxy-3-methylnaphthalen-2-yl)ethanone |
|---|---|
| Synonyms |
Ethanone, 1-(1,8-dihydroxy-3-methyl-2-naphthalenyl)-
Dianellidin dianellidine 1,8-dihydroxy-2-acetyl-3-methylnaphthalene 1-(1,8-Dihydroxy-3-methyl-2-naphthyl)ethanone 1-(1,8-Dihydroxy-3-methyl-2-naphthalenyl)ethanone Musizin 2-acetyl-1,8-dihydroxy-3-methylnaphthalene Nepodin |
| Description | Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities. |
|---|---|
| Related Catalog | |
| In Vitro | Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1]. |
| In Vivo | Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2]. Animal Model: C57BL/KsJ-db/db mice[2] Dosage: 2 mg/kg; 10 mg/kg Administration: Orally administration; 2-10 mg/kg; 4 weeks Result: Had antihyperglycemic potential and improved insulin resistance. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 413.2±40.0 °C at 760 mmHg |
| Melting Point | 165-166℃ (methanol ) |
| Molecular Formula | C13H12O3 |
| Molecular Weight | 216.233 |
| Flash Point | 217.8±23.8 °C |
| Exact Mass | 216.078644 |
| PSA | 57.53000 |
| LogP | 2.87 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.668 |
| HS Code | 2914400090 |
|---|
|
~87%
3785-24-8 |
| Literature: Rizzacasa, Mark A.; Sargent, Melvyn V. Australian Journal of Chemistry, 1988 , vol. 41, # 7 p. 1087 - 1097 |
|
~%
3785-24-8 |
| Literature: Rizzacasa, Mark A.; Sargent, Melvyn V. Australian Journal of Chemistry, 1988 , vol. 41, # 7 p. 1087 - 1097 |
| Precursor 2 | |
|---|---|
| DownStream 1 | |
| HS Code | 2914400090 |
|---|---|
| Summary | 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |