114828-90-9
114828-90-9 structure
- Name: Endoxifen (E-isomer)
- Chemical Name: (E)-4-Hydroxy-N-desmethyl Tamoxifen
- CAS Number: 114828-90-9
- Molecular Formula: C25H27NO2
- Molecular Weight: 373.48700
- Catalog: Research Areas Cancer
- Create Date: 2016-07-21 03:08:57
- Modify Date: 2024-01-09 10:34:33
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Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. (Z)-Endoxifen, an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen.
| Name | (E)-4-Hydroxy-N-desmethyl Tamoxifen |
|---|---|
| Synonyms |
4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
Endoxifen (E-isomer) |
| Description | Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. (Z)-Endoxifen, an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen. |
|---|---|
| Related Catalog | |
| In Vitro | Endoxifen exists as the potently anti-estrogenic (Z)-isomer and the lesser known (E)-isomer. It is assumed that (E)-Endoxifen, structurally related to (E)-4-OH-tamoxifen, have similar pharmacological properties. The (E)-isomer is an impurity in (Z)-Endoxifen drug substance and increases under certain storage conditions. (E)-Endoxifen is identified as the primary degradant[1]. |
| References |
| Molecular Formula | C25H27NO2 |
|---|---|
| Molecular Weight | 373.48700 |
| Exact Mass | 373.20400 |
| PSA | 41.49000 |
| LogP | 5.75040 |
| Storage condition | 2-8℃ |
|
~%
114828-90-9 |
| Literature: Fauq, Abdul H.; Maharvi, Ghulam M.; Sinha, Dola Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 10 p. 3036 - 3038 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |