Endoxifen (E-isomer)

Modify Date: 2024-01-09 10:34:33

Endoxifen (E-isomer) structure	Common Name	Endoxifen (E-isomer)
	CAS Number	114828-90-9	Molecular Weight	373.48700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₇NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Endoxifen (E-isomer)

Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. (Z)-Endoxifen, an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen.

Name	(E)-4-Hydroxy-N-desmethyl Tamoxifen
Synonym	More Synonyms

Description	Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. (Z)-Endoxifen, an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen.
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
In Vitro	Endoxifen exists as the potently anti-estrogenic (Z)-isomer and the lesser known (E)-isomer. It is assumed that (E)-Endoxifen, structurally related to (E)-4-OH-tamoxifen, have similar pharmacological properties. The (E)-isomer is an impurity in (Z)-Endoxifen drug substance and increases under certain storage conditions. (E)-Endoxifen is identified as the primary degradant[1].
References	[1]. Elkins P, et al. Characterization of the isomeric configuration and impurities of (Z)-Endoxifen by 2D NMR, high resolution LC-MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.

Molecular Formula	C₂₅H₂₇NO₂
Molecular Weight	373.48700
Exact Mass	373.20400
PSA	41.49000
LogP	5.75040
Storage condition	2-8℃

N/A structure

N/A

CAS#:1231730-32-7

Phenyl ethyl ketone structure

Phenyl ethyl ketone

CAS#:93-55-0

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Endoxifen (E-isomer) Structure

Endoxifen (E-isomer)

CAS#:114828-90-9

Endoxifen (Z-isomer hydrochloride) structure

Endoxifen (Z-is...

CAS#:1032008-74-4

Literature: Fauq, Abdul H.; Maharvi, Ghulam M.; Sinha, Dola Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 10 p. 3036 - 3038

Precursor 1
CAS#:93-55-0 Phenyl ethyl ketone
DownStream 0

4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

Endoxifen (E-isomer)

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Email: enquiry@dycnchem.com

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