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20636-48-0

20636-48-0 structure
20636-48-0 structure
  • Name: Nonylbenzene-PEG5-OH
  • Chemical Name: 2-[2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
  • CAS Number: 20636-48-0
  • Molecular Formula: C25H44O6
  • Molecular Weight: 440.61300
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-04-09 08:00:00
  • Modify Date: 2024-01-12 19:55:45
  • Nonylbenzene-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-[2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonyms polyoxyethylene(5) nonylphenyl ether
nonylphenol ethoxylate
Igepal CO-520
3,6,9,12-Tetraoxatetradecan-1-ol,14-(4-nonylphenoxy)
4-nonylphenol pentaethoxylate
Description Nonylbenzene-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.016g/cm3
Boiling Point 541.2ºC at 760 mmHg
Molecular Formula C25H44O6
Molecular Weight 440.61300
Flash Point 281.1ºC
Exact Mass 440.31400
PSA 66.38000
LogP 4.41720
Vapour Pressure 1.52E-12mmHg at 25°C
Index of Refraction 1.489
Storage condition 2-8°C
HS Code 2918990090
HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%