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57671-28-0

57671-28-0 structure
57671-28-0 structure
  • Name: BnO-PEG5-OH
  • Chemical Name: Pentaethylene Glycol Monobenzyl Ether
  • CAS Number: 57671-28-0
  • Molecular Formula: C17H28O6
  • Molecular Weight: 328.401
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-02-21 08:00:00
  • Modify Date: 2024-01-15 01:06:54
  • BnO-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Name Pentaethylene Glycol Monobenzyl Ether
Synonyms 2,5,8,11,14-Pentaoxahexadecan-16-ol, 1-phenyl-
1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-ol
2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
Description BnO-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Girardini M, et al. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg Med Chem. 2019 Jun 15;27(12):2466-2479.

Density 1.1±0.1 g/cm3
Boiling Point 437.2±40.0 °C at 760 mmHg
Molecular Formula C17H28O6
Molecular Weight 328.401
Flash Point 218.2±27.3 °C
Exact Mass 328.188599
PSA 66.38000
LogP -0.18
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.497
HS Code 2909499000
HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%