78954-23-1

78954-23-1 structure

Name: Yakuchinone A
Chemical Name: 1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone
CAS Number: 78954-23-1
Molecular Formula: C₂₀H₂₄O₃
Molecular Weight: 312.40
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-11 17:29:59
Modify Date: 2024-01-12 10:59:48
Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities[1].

Name	1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone
Synonyms	yakuchinone-A 1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-3-heptanone yadanzioside-N

Description	Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology
In Vitro	Yakuchinone A 作用于 A375P、B16F1、B16F10、A549、MCF-7 和 HT-29 细胞系的 IC50 值分别是 14.75、31.73、21.71、26.07 、11.50 和 11.96[1]。 Yakuchinone A (0-64 μM, 16 h) 可以剂量依赖性方式减少 IL-17 的产生，在 EL4（小鼠淋巴瘤细胞系）细胞中的 IC50 值为 11.5 μM[2] 。
In Vivo	Yakuchinone A (50 mg/kg, i.p., daily, 14 days) 在自身免疫性脑脊髓炎 (EAE) 小鼠模型中可以减轻小鼠的 EAE 症状[1]。 Animal Model: Female C57BL/6 mice[1] Dosage: 50 mg/kg Administration: i.p., daily, 14 days Result: Showed a significant EAE score reduction from Day 9 to Day 15 after EAE onset.
References	[1]. Chen Huo, et al. Microbial Transformation of Yakuchinone A and Cytotoxicity Evaluation of Its Metabolites. Int J Mol Sci. 2022 Apr 3;23(7):3992. [2]. Kuo-Kuei Huang, et al. Alpinia oxyphylla Fruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells. Evid Based Complement Alternat Med. 2019 Mar 14;2019:6797030.