Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Argpressin acetate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
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75499-44-4

75499-44-4 structure

Name: Argpressin acetate
Chemical Name: <8-arginine>vasopressin
CAS Number: 75499-44-4
Molecular Formula: C₄₈H₆₉N₁₅O₁₄S₂
Molecular Weight: 1144.28000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-02-27 11:17:39
Modify Date: 2024-01-17 20:44:57
Arginine vasopressin (AVP, also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. AVP can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). AVP also have potentially important effects on centrally regulated metabolic processes[1].

Name	<8-arginine>vasopressin
Synonyms	Arginine Vasopressin Diacetate

Description	Arginine vasopressin (AVP, also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. AVP can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). AVP also have potentially important effects on centrally regulated metabolic processes[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
In Vitro	AVP induces proliferation and prevented cytokine-induced apoptosis in rodent and human beta-cells[1]. Cell Proliferation Assay[1] Cell Line: clonal BRIN BD11 and 1.1B4 cells Concentration: 10-6 M Incubation Time: 2 h Result: Increased proliferation of rodent and human beta-cells. Apoptosis Analysis[1] Cell Line: clonal BRIN BD11 and 1.1B4 cells Concentration: 10-6 M Incubation Time: 2 h Result: Protected against cytokine-induced beta-cell apoptosis.
In Vivo	AVP (25 nmol/kg bw; intraperitoneal injection; once) significantly reduces overall AUC glucose values，but not increases insulin levels in mice[1]. Animal Model: NIH Swiss mice (adult; male; 12-14weeks) [1] Dosage: 25 nmol/kg bw Administration: AVP (25 nmol/kg bw; intraperitoneal injection; once) Result: Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice.
References	[1]. Shruti Mohan, et al. Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival. Biochimie

Molecular Formula	C₄₈H₆₉N₁₅O₁₄S₂
Molecular Weight	1144.28000
Exact Mass	1143.46000
PSA	549.33000
LogP	1.25190

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