Henan Tianfu Chemical Co., Ltd.
China
Product Name: broussochalcone A
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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99217-68-2

99217-68-2 structure

Name: Broussochalcone A
Chemical Name: (E)-1-[2,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
CAS Number: 99217-68-2
Molecular Formula: C₂₀H₂₀O₅
Molecular Weight: 340.37000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-02-16 04:01:43
Modify Date: 2024-04-05 17:19:59
Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways[1][2].

Name	(E)-1-[2,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
Synonyms	2-Propen-1-one,1-(2,4-dihydroxy-5-(3-methyl-2-butenyl)phenyl)-3-(3,4-dihydroxyphenyl)-,(E) Broussochalcone A

Description	Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
In Vitro	Broussochalcone A (0.3, 1, and 3 μM; 10 min, 再 Fe 诱导 30 min) 在大鼠脑匀浆中抑制 Fe2+ (200 μM) 诱导的脂质过氧化[1]。 Broussochalcone A (1-30 μM; 30 min) 剂量依赖性增加 DPPH (100 μM) 的清除活性[1]。 Broussochalcone A (0.1-1 μM) 抑制细胞色素 c 还原，IC50 为 0.5 μM，这主要是由于其清除超氧阴离子活性，部分是由于其抑制黄嘌呤氧化酶活性[1]。 Broussochalcone A (1-20 μM; 24 h) 抑制亚硝酸盐的产生和 iNOS 蛋白的表达[1]。 Western Blot Analysis[1] Cell Line: LPS-activated RAW 264.7 macrophages Concentration: 1 μM, 3 μM, 10 μM, 20 μM Incubation Time: 30 min; then stimulated by LPS (1 μg/mL) for another 24 hr Result: Caused inhibition of iNOS protein expression dose-dependently. Inhibited IkBα phosphorylation.
References	[1]. Cheng Z, et al. Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Biochem Pharmacol. 2001 Apr 15;61(8):939-46. [2]. Lee HK, et al. Broussochalcone A Induces Apoptosis in Human Renal Cancer Cells via ROS Level Elevation and Activation of FOXO3 Signaling Pathway. Oxid Med Cell Longev. 2021 Oct 27;2021:2800706.

Density	1.312g/cm3
Boiling Point	595ºC at 760 mmHg
Molecular Formula	C₂₀H₂₀O₅
Molecular Weight	340.37000
Flash Point	327.7ºC
Exact Mass	340.13100
PSA	97.99000
LogP	3.91380
Index of Refraction	1.679

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