1050-28-8

1050-28-8 structure

Name: H-Tyr-Tyr-OH
Chemical Name: L-tyrosyl-L-tyrosine
CAS Number: 1050-28-8
Molecular Formula: C₁₈H₂₀N₂O₅
Molecular Weight: 344.36200
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2016-05-23 07:24:03
Modify Date: 2024-01-03 09:26:28
H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme (ACE) with an IC50 value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure[1][2].

Name	L-tyrosyl-L-tyrosine
Synonyms	h-tyr-tyr-oh

Description	H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme (ACE) with an IC50 value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Target	IC50: 0.028 mg/mL (ACE)[2]
In Vitro	H-Tyr-Tyr-OH shows inhibitory effect against ACE with an IC50 value of 0.028 mg/mL[2].
In Vivo	H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo[1]. H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats[1]. Animal Model: Anesthetized male SpragueDawley rats[1] Dosage: 12.5 mg/kg Administration: Intraarterial injection; 12.5 mg/kg once Result: Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration. Animal Model: Spontaneously hypertensive rats[1] Dosage: 0, 50 and 100 mg/kg Administration: Intraperitoneal injection; once Result: Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.
References	[1]. Maher TJ, et al. Use of parenteral dipeptides to increase serum tyrosine levels and to enhance catecholamine-mediated neurotransmission. J Pharm Sci. 1990 Aug;79(8):685-7. [2]. Maruyama, et al. Purification and identification of angiotensin I-converting enzyme inhibitory peptides from Royal Jelly treated with protease. Nippon Shokuhin Kagaku Kogaku Kaishi. 2003.

Molecular Formula	C₁₈H₂₀N₂O₅
Molecular Weight	344.36200
Exact Mass	344.13700
PSA	132.88000
LogP	1.87090
Vapour Pressure	9.55E-21mmHg at 25°C

10417-83-1

1050-28-8

Literature: Abderhalden et al. Fermentforschung, 1942 , vol. 16, p. 98,114 Bergmann et al. Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1934 , vol. 224, p. 17,24

Precursor 1
10417-83-1
DownStream 3
538-86-3 60-18-4 14191-95-8

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