Name | 3β,16α,23,28-Tetrahydroxyoleana-11(12),13(18)-diene |
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Synonyms |
(3β,16α)-Oleana-11,13(18)-diene-3,16,23,28-tetrol
Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,16α)- Saikogenin D |
Description | Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2]. |
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Related Catalog | |
In Vitro | Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells[1]. Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells[1]. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 607.4±55.0 °C at 760 mmHg |
Melting Point | 261-266 °C |
Molecular Formula | C30H48O4 |
Molecular Weight | 472.700 |
Flash Point | 252.4±26.1 °C |
Exact Mass | 472.355255 |
PSA | 80.92000 |
LogP | 5.38 |
Vapour Pressure | 0.0±3.9 mmHg at 25°C |
Index of Refraction | 1.586 |