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5573-16-0

5573-16-0 structure
5573-16-0 structure
  • Name: Saikogenin D
  • Chemical Name: 3β,16α,23,28-Tetrahydroxyoleana-11(12),13(18)-diene
  • CAS Number: 5573-16-0
  • Molecular Formula: C30H48O4
  • Molecular Weight: 472.700
  • Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
  • Create Date: 2018-08-11 15:09:53
  • Modify Date: 2024-01-03 09:56:05
  • Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2].

Name 3β,16α,23,28-Tetrahydroxyoleana-11(12),13(18)-diene
Synonyms (3β,16α)-Oleana-11,13(18)-diene-3,16,23,28-tetrol
Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,16α)-
Saikogenin D
Description Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2].
Related Catalog
In Vitro Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells[1]. Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells[1].
References

[1]. Toriniwa Y, et al. Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis.J Pharm Pharmacol. 2006 Jun;58(6):859-66.

[2]. Kodama Y, et al. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.Planta Med. 2003 Aug;69(8):765-7.

Density 1.2±0.1 g/cm3
Boiling Point 607.4±55.0 °C at 760 mmHg
Melting Point 261-266 °C
Molecular Formula C30H48O4
Molecular Weight 472.700
Flash Point 252.4±26.1 °C
Exact Mass 472.355255
PSA 80.92000
LogP 5.38
Vapour Pressure 0.0±3.9 mmHg at 25°C
Index of Refraction 1.586