1493764-08-1
1493764-08-1 structure
- Name: UNC 2881
- Chemical Name: 5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-
- CAS Number: 1493764-08-1
- Molecular Formula: C25H33N7O2
- Molecular Weight: 463.575
- Catalog: Biochemical Inhibitor Protein tyrosine kinase
- Create Date: 2018-12-03 11:30:44
- Modify Date: 2024-01-02 16:55:02
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UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. IC50 value: 22 nM [1]Target: Mer kinase inhibitorTreatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis.
| Name | 5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]- |
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| Synonyms |
5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-
2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[4-(1H-imidazol-1-yl)benzyl]-5-pyrimidinecarboxamide UNC2881 |
| Description | UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. IC50 value: 22 nM [1]Target: Mer kinase inhibitorTreatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C25H33N7O2 |
| Molecular Weight | 463.575 |
| Exact Mass | 463.269562 |
| PSA | 116.99000 |
| LogP | 3.03 |
| Index of Refraction | 1.666 |
| Storage condition | -20℃ |
| Water Solubility | Insuluble (1.7E-3 g/L) (25 ºC) |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |