23288-49-5
23288-49-5 structure
- Name: Probucol
- Chemical Name: probucol
- CAS Number: 23288-49-5
- Molecular Formula: C31H48O2S2
- Molecular Weight: 516.842
- Catalog: API Circulatory system medication Regulating blood lipids
- Create Date: 2018-02-08 08:00:00
- Modify Date: 2024-01-03 12:05:12
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Probucol is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.Target: OthersProbucol is a drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. Probucol inhibited cholesterol efflux up to 80% in J774 macrophages expressing ABCA1. probucol is an effective inhibitor of ABCA1-mediated cholesterol efflux without influencing scavenger receptor class B type I-mediated efflux. The inhibition of ABCA1 translocation to the plasma membrane may in part explain the reported in vivo high-density lipoprotein-lowering action of probucol [1].
| Name | probucol |
|---|---|
| Synonyms |
4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol]
Biphenabid Phenol, 4,4'-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)- Lursell EINECS 245-560-9 Probucol 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol Acetone Bis(3,5-di-tert-butyl-4-hydroxyphenyl)mercaptole Bisbid [14C]-Probucol Panavir Sinlestal Lurselle 4,4'-((1-methylethylidene)-bis(thio))-bis(2,6-bis(1,1-dimethylethyl)phenol) 4,4'-[(1-methylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol] 4,4'-(propane-2,2-diyldisulfanediyl)bis(2,6-di-tert-butylphenol) 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol] Probucolum MFCD00079281 Lesterol Lorelco Bisphenabid 4,4'-(isopropylidenedithio)-bis-(2,6-di-tert-butylphenol) 4,4'-(2,2-Propanediyldisulfanediyl)bis[2,6-bis(2-methyl-2-propanyl)phenol] |
| Description | Probucol is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.Target: OthersProbucol is a drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. Probucol inhibited cholesterol efflux up to 80% in J774 macrophages expressing ABCA1. probucol is an effective inhibitor of ABCA1-mediated cholesterol efflux without influencing scavenger receptor class B type I-mediated efflux. The inhibition of ABCA1 translocation to the plasma membrane may in part explain the reported in vivo high-density lipoprotein-lowering action of probucol [1]. |
|---|---|
| Related Catalog | |
| References |
[1]. Probucol |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 546.7±50.0 °C at 760 mmHg |
| Melting Point | 117 118ºC |
| Molecular Formula | C31H48O2S2 |
| Molecular Weight | 516.842 |
| Flash Point | 264.9±28.8 °C |
| Exact Mass | 516.309570 |
| PSA | 91.06000 |
| LogP | 10.27 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.574 |
| Storage condition | Desiccate at +4°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S23-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AL3705000 |
| HS Code | 29093090 |
|
~82%
23288-49-5 |
| Literature: Sumitomo Chemical Company, Limited Patent: EP1849768 A1, 2007 ; Location in patent: Page/Page column 5 ; |
| Precursor 2 | |
|---|---|
| DownStream 9 | |
![2,6-ditert-butyl-4-[(3,5-ditert-butyl-4-hydroxyphenyl)disulfanyl]phenol structure](https://image.chemsrc.com/caspic/049/6386-58-9.png)
![2,6-ditert-butyl-4-[(3,5-ditert-butyl-4-hydroxyphenyl)trisulfanyl]phenol structure](https://image.chemsrc.com/caspic/108/6386-61-4.png)
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |