Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Probucol
Price:
Purity: 99.0%
Stocking Period: 10 Day
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DC Chemicals Limited
China
Product Name: Probucol
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Probucol
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

23288-49-5

23288-49-5 structure

Name: Probucol
Chemical Name: probucol
CAS Number: 23288-49-5
Molecular Formula: C₃₁H₄₈O₂S₂
Molecular Weight: 516.842
Catalog: API Circulatory system medication Regulating blood lipids
Create Date: 2018-02-08 08:00:00
Modify Date: 2024-01-03 12:05:12
Probucol is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.Target: OthersProbucol is a drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. Probucol inhibited cholesterol efflux up to 80% in J774 macrophages expressing ABCA1. probucol is an effective inhibitor of ABCA1-mediated cholesterol efflux without influencing scavenger receptor class B type I-mediated efflux. The inhibition of ABCA1 translocation to the plasma membrane may in part explain the reported in vivo high-density lipoprotein-lowering action of probucol [1].

Name	probucol
Synonyms	4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol] Biphenabid Phenol, 4,4'-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)- Lursell EINECS 245-560-9 Probucol 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol Acetone Bis(3,5-di-tert-butyl-4-hydroxyphenyl)mercaptole Bisbid [14C]-Probucol Panavir Sinlestal Lurselle 4,4'-((1-methylethylidene)-bis(thio))-bis(2,6-bis(1,1-dimethylethyl)phenol) 4,4'-[(1-methylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol] 4,4'-(propane-2,2-diyldisulfanediyl)bis(2,6-di-tert-butylphenol) 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol] Probucolum MFCD00079281 Lesterol Lorelco Bisphenabid 4,4'-(isopropylidenedithio)-bis-(2,6-di-tert-butylphenol) 4,4'-(2,2-Propanediyldisulfanediyl)bis[2,6-bis(2-methyl-2-propanyl)phenol]

Description	Probucol is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.Target: OthersProbucol is a drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. Probucol inhibited cholesterol efflux up to 80% in J774 macrophages expressing ABCA1. probucol is an effective inhibitor of ABCA1-mediated cholesterol efflux without influencing scavenger receptor class B type I-mediated efflux. The inhibition of ABCA1 translocation to the plasma membrane may in part explain the reported in vivo high-density lipoprotein-lowering action of probucol [1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Natural Products >> Phenols
References	[1]. Probucol

Density	1.1±0.1 g/cm3
Boiling Point	546.7±50.0 °C at 760 mmHg
Melting Point	117 118ºC
Molecular Formula	C₃₁H₄₈O₂S₂
Molecular Weight	516.842
Flash Point	264.9±28.8 °C
Exact Mass	516.309570
PSA	91.06000
LogP	10.27
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.574
Storage condition	Desiccate at +4°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AL3705000

CHEMICAL NAME :: Acetone, bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole

CAS REGISTRY NUMBER :: 23288-49-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C31-H48-O2-S2

MOLECULAR WEIGHT :: 516.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 3650 mg/kg/1Y-I

TOXIC EFFECTS :: Behavioral - general anesthetic Cardiac - cardiomegaly Cardiac - pulse rate increase, without fall in BP

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 326,1435,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1042,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1042,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 40,833,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1042,1990

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S23-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AL3705000
HS Code	29093090

950-59-4

67-64-1

~82%

23288-49-5

Literature: Sumitomo Chemical Company, Limited Patent: EP1849768 A1, 2007 ; Location in patent: Page/Page column 5 ;

Precursor 2
950-59-4 67-64-1
DownStream 9
110-94-1 719-22-2 6386-58-9 6386-61-4
2455-14-3 216167-82-7 216168-45-5 216167-95-2
110-15-6

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

23288-49-5	1173019-29-8
216168-45-5	81075-13-0
216167-82-7	2455-14-3