87272-20-6

87272-20-6 structure

Name: MEDICA 16
Chemical Name: 3,3,14,14-tetramethylhexadecanedioic acid
CAS Number: 87272-20-6
Molecular Formula: C₂₀H₃₈O₄
Molecular Weight: 342.513
Catalog: Signaling Pathways GPCR/G Protein GPR120
Create Date: 2019-02-02 12:38:17
Modify Date: 2024-01-19 11:27:30
MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120[1][2].

Name	3,3,14,14-tetramethylhexadecanedioic acid
Synonyms	3,3,14,14-Tetramethylhexanedecanedioic acid 3,3,14,14-tetramethyl-1,16-hexadecanedioic acid MEDICA 16 Medic-16 3,3,14,14-tetramethyl-hexadecanedioic acid 3,3,14,14-Tetramethylhexadecanedioic acid Hexadecandioic acid,3,3,14,14-tetramethyl 3,3,14,14-tetramethyl-hexadecane-1,16-dioic acid Hexadecanedioic acid, 3,3,14,14-tetramethyl- MFCD00797684

Description	MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR120 Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase Signaling Pathways >> GPCR/G Protein >> GPR40 Research Areas >> Metabolic Disease
References	[1]. Atkinson LL, et al. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats. Diabetes. 2002;51(5):1548-1555. [2]. Hara T, Hirasawa A, Sun Q, et al. Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol. 2009;380(3):247-255.

HS Code	2917190090

87272-21-7

87272-20-6

Literature: WO2008/18877 A1, ; Page/Page column 20; 40-41 ;

Precursor 1
87272-21-7
DownStream 0

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%