149234-05-9

149234-05-9 structure

Name: H-ILE-ARG-VAL-VAL-MET-OH
Chemical Name: h-ile-arg-val-val-met-oh
CAS Number: 149234-05-9
Molecular Formula: C₂₇H₅₂N₈O₆S
Molecular Weight: 616.81700
Catalog: Research Areas Cancer
Create Date: 2016-02-18 16:05:43
Modify Date: 2024-01-12 20:54:14
H-ILE-ARG-VAL-VAL-MET-OH is a pentapeptide from C7 with a domain that supports cell attachment. H-ILE-ARG-VAL-VAL-MET-OH is also the sequence fragment that binds to the thrombospondin-1 (TS1) receptor[1][2].

Name	h-ile-arg-val-val-met-oh
Synonyms	ile-arg-val-val-met

Description	H-ILE-ARG-VAL-VAL-MET-OH is a pentapeptide from C7 with a domain that supports cell attachment. H-ILE-ARG-VAL-VAL-MET-OH is also the sequence fragment that binds to the thrombospondin-1 (TS1) receptor[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Thrombospondin-1 (TS1) receptor[2]
In Vitro	H-ILE-ARG-VAL-VAL-MET-OH 支持 G361 黑色素瘤、K562 红白血病细胞、HT1080 纤维肉瘤、C32 无色素黑色素瘤和内皮细胞的附着。H-ILE-ARG-VAL-VAL-MET-OH 还抑制细胞与 TS1 的重组细胞结合域 (CBD) 的粘附[1]。
References	[1]. Kosfeld MD, et al. Identification of a new cell adhesion motif in two homologous peptides from the COOH-terminal cell binding domain of human thrombospondin. J Biol Chem. 1993 Apr 25;268(12):8808-14. [2]. Frazier, et al. Thrombospondin 1 subfragments that bind to thrombospondin 1 receptor and inhibit cell adhesion: United States, US5399667[P]. 1995-03-21.