- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: isoleucyl-lysyl-valyl-alanyl-valine
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate salt
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Vinnie
131167-89-0
131167-89-0 structure
- Name: H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate salt
- Chemical Name: Laminin-1 peptide
- CAS Number: 131167-89-0
- Molecular Formula: C25H48N6O6
- Molecular Weight: 528.685
- Catalog: Signaling Pathways MAPK/ERK Pathway ERK
- Create Date: 2018-05-21 08:00:00
- Modify Date: 2024-01-02 16:33:53
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H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2].
| Name | Laminin-1 peptide |
|---|---|
| Synonyms |
L-Isoleucyl-L-lysyl-L-valyl-L-alanyl-L-valine
L-Valine, L-isoleucyl-L-lysyl-L-valyl-L-alanyl- |
| Description | H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2]. |
|---|---|
| Related Catalog | |
| Target |
ERK1 ERK2 Akt |
| In Vitro | H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) 诱导骨髓间充质干细胞(BMMSC)增殖和增殖细胞核抗原(PCNA)合成[2]。 H-Ile-Lys-Val-Ala-Val-OH (5 mM, 24 h) 诱导 BMMSC 细胞周期，使细胞从 G0/G1 进入 S 期并阻止它们进入 G2/M 期[2]。 H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) 通过增强 BMMSCs 中 ERK1/2 和 Akt 的磷酸化水平激活 MAPK/ERK 和 PI3K/Akt 信号通路[2]。 Cell Proliferation Assay[2] Cell Line: BMMSC Concentration: 0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM Incubation Time: 0, 12, 24, 36, 48 h Result: Stimulated proliferating cell nuclear antigen (PCNA) synthesis and induced proliferation of bone marrow mesenchymal stem cell (BMMSC) in a dose- and time-dependent manner. Cell Cycle Analysis[2] Cell Line: BMMSC Concentration: 5 mM Incubation Time: 24 h Result: Induced the BMMSC cell cycle for cells to enter S phase from G0/G1 and arrested them from entering G2/M phase; the increased proportion of S phase in cell cycle was considered to be a sign of BMMSC proliferation. Western Blot Analysis[2] Cell Line: BMMSC Concentration: 0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM Incubation Time: 0, 12, 24, 36, 48 h Result: Increased significantly the levels of p-ERK1/2 and p-Akt in a dose- and time-dependent manner. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 856.6±65.0 °C at 760 mmHg |
| Molecular Formula | C25H48N6O6 |
| Molecular Weight | 528.685 |
| Flash Point | 471.9±34.3 °C |
| Exact Mass | 528.363525 |
| LogP | 1.27 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.511 |