Shanghai Nianxing Industrial Co., Ltd
China
Product Name: phenformin
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: phenformin
Price: ￥1128.0/1g ￥478.0/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Henan Tianfu Chemical Co., Ltd.
China
Product Name: PhenforMin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

114-86-3

114-86-3 structure

Name: phenformin
Chemical Name: phenformin
CAS Number: 114-86-3
Molecular Formula: C₁₀H₁₅N₅
Molecular Weight: 205.260
Catalog: API Hormone and endocrine-regulating drugs Pancreatic hormones and other blood sugar regulating drugs
Create Date: 2018-09-10 11:39:18
Modify Date: 2024-01-03 10:50:46
Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].

Name	phenformin
Synonyms	[3H]-Phenformin Fenformin Normoglucina 1-(diaminomethylidene)-2-(2-phenylethyl)guanidine [14C]-Phenformin 1-phenethylbiguanide MFCD00035039 Imidodicarbonimidic diamide, N-(2-phenylethyl)- Feguanide Phenforminum phenylethyl biguanide phenethylbiguanide Phenformine EINECS 204-057-4 phenformin Cronoformin Fenfoduron Fenformina N-(2-Phenylethyl)imidodicarbonimidic diamide

Description	Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Metabolic Disease
References	[1]. García Rubiño ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20(13):3316. [2]. Yendapally R, et al. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020 Jun;81(4):390-401.

Density	1.2±0.1 g/cm3
Boiling Point	332.2±35.0 °C at 760 mmHg
Melting Point	280-282°C
Molecular Formula	C₁₀H₁₅N₅
Molecular Weight	205.260
Flash Point	154.7±25.9 °C
Exact Mass	205.132751
PSA	97.78000
LogP	-0.60
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.620
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU2100000

CHEMICAL NAME :: Biguanide, 1-phenethyl-

CAS REGISTRY NUMBER :: 114-86-3

BEILSTEIN REFERENCE NO. :: 1977317

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H15-N5

MOLECULAR WEIGHT :: 205.30

WISWESSER LINE NOTATION :: MUYZMYUM&M2R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 42,236,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 42,236,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 97,396,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 8,237,1963

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - metabolic acidosis

REFERENCE :: 43ZRAD "Hemoperfusion: Kidney and Liver Support and Detoxification, Proceedings of the International Symposium, Haifa, 1979," Sideman, S., and T.M.S. Chang, eds., Multiple parts, New York, Hemisphere Pub. Corp., 1980- Volume(issue)/page/year: 1,337,1980

Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S36
WGK Germany	3
RTECS	DU2200000

834-28-6

~84%

114-86-3

Literature: Bioorganic and Medicinal Chemistry, , vol. 21, # 8 p. 2305 - 2313

156-28-5

127099-85-8

114-86-3

Literature: Journal of the American Chemical Society, , vol. 81, p. 2220,2223

Precursor 2
834-28-6 156-28-5
DownStream 1
79246-47-2

114-86-3	834-28-6
926-81-8	1158522-08-7
946212-53-9	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	1375289-11-4