Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: FORTIMICIN
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55779-06-1

55779-06-1 structure

Name: FORTIMICIN
Chemical Name: astromicin
CAS Number: 55779-06-1
Molecular Formula: C₁₇H₃₅N₅O₆
Molecular Weight: 405.49000
Catalog: API Antibiotics Aminoglycoside
Create Date: 2018-09-28 21:18:21
Modify Date: 2024-01-13 12:13:24
Astromicin (KW-1070) is a water-soluble aminoglycoside antibiotic that can be isolated from the genus Micromonospora. Astromicin exhibits broad spectrum antibacterial activity against gram positive and negative bacteria[1][2][3].

Name	astromicin
Synonyms	antibiotickw-1070 XK-70-1 FORTIMYCIN ASTROMICIN SULPHATE Fortimycin A ASTROMYCIN FORTIMICIN fortimicina kw-1070

Description	Astromicin (KW-1070) is a water-soluble aminoglycoside antibiotic that can be isolated from the genus Micromonospora. Astromicin exhibits broad spectrum antibacterial activity against gram positive and negative bacteria[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Astromicin 的体外抗菌活性[3] Bacillus subtilis KY 4273 Staphylococcus aureus ATCC 6538P Streptococcus faecalis ATCC 10541 Escherichia coli ATCC 26 E.coli KY 8310 Klebsiella pneumoniae ATCC 10031 Pseudomonas aeruginosa KY 4276 Proteus vulgaris ATCC 6897 Shigella sonnei ATCC 9290 Salmonella typhosa ATCC 9992 MIC (µg/mL) 0.02 0.04 10 0.16 0.13 0.08 5 0.16 0.3 0.08 E.coli ATCC 26 E.coli KY 8302 E.coli KY 8321 E.coli KY 8327 E.coli KY 8332 E.coli KY 8349 Providencia sp. 164 Serratia marcescens POE 1065 MIC (µg/mL) 0.16 0.16 0.08 0.32 0.04 0.08 0.63 0.32
In Vivo	Astromicin (3.7 mg/kg 和 5.8 mg/kg；皮下注射；单剂量) 对感染 S.aureus Smith 或 E.coli Juhl 的小鼠具有保护作用[3]。
References	[1]. Dairi T, et al. Organization and nature of fortimicin A (astromicin) biosynthetic genes studied using a cosmid library of Micromonospora olivasterospora DNA. Mol Gen Genet. 1992 Dec;236(1):39-48. [2]. Kawamoto T, et al. Determination of sisomicin, netilmicin, astromicin and micronomicin in serum by high-performance liquid chromatography. J Chromatogr. 1984 Feb 10;305(2):373-9. [3]. Nara T, et al. Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation and biological properties of fortimicins. J Antibiot (Tokyo). 1977 Jul;30(7):533-40.

Density	1.31g/cm3
Boiling Point	621.1ºC at 760mmHg
Melting Point	>200° (dec)
Molecular Formula	C₁₇H₃₅N₅O₆
Molecular Weight	405.49000
Flash Point	329.4ºC
Exact Mass	405.25900
PSA	192.54000

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM7521490

CHEMICAL NAME :: L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O- (2,6-diamino- 2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O- methyl-

CAS REGISTRY NUMBER :: 55779-06-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H35-N5-O6

MOLECULAR WEIGHT :: 405.57

WISWESSER LINE NOTATION :: T6OTJ CZ FYZ1 BO- AL6TJ BZ CQ DO1 EN1&V1Z FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 97 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 29,543,1986

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