GL Biochem (Shanghai) Ltd.
China
Product Name: Boc-azetidine-3-carboxylic acid
Price: ￥Inquiry/1kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1-Boc-azetidine-3-carboxylic acid
Price: ￥58.0/250mg ￥178.0/5g ￥78.0/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: 1-Boc-azetidine-3-carboxylic acid
Price: ￥Inquiry/100g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Lihua Yang

DC Chemicals Limited
China
Product Name: 1-Boc-azetidine-3-carboxylic acid
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

142253-55-2

142253-55-2 structure

Name: 1-Boc-azetidine-3-carboxylic acid
Chemical Name: 1-Boc-3-Azetidine-3-carboxylic acid
CAS Number: 142253-55-2
Molecular Formula: C₉H₁₅NO₄
Molecular Weight: 201.220
Catalog: Biochemical Amino acids and their derivatives BOC-amino acid
Create Date: 2018-10-07 16:45:24
Modify Date: 2024-01-02 20:16:02
1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]

Name	1-Boc-3-Azetidine-3-carboxylic acid
Synonyms	1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-azetidinecarboxylic acid 1-N-Boc-3-Azetidinecarboxylic Acid 1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-3-carboxylic acid MFCD01860897 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid N-Boc-Azetidine-3-carboxylic acid 1-BOC-Azetidine-3-carboxylic acid 1-Boc-azetidine-3-carboxylicacid

Description	1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.2±0.1 g/cm3
Boiling Point	321.0±35.0 °C at 760 mmHg
Melting Point	100.1-101.9°C
Molecular Formula	C₉H₁₅NO₄
Molecular Weight	201.220
Flash Point	147.9±25.9 °C
Exact Mass	201.100113
PSA	66.84000
LogP	0.27
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.510
Storage condition	Store at -15°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	S22-S24/25-S37-S26
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

24424-99-5

36476-78-5

~97%

142253-55-2

Literature: AstraZeneca AB Patent: US2008/171732 A1, 2008 ; Location in patent: Page/Page column 36 ; US 20080171732 A1

24424-99-5

102624-96-4

~58%

142253-55-2

Literature: BOEHRINGER INGELHEIM INTERNATIONAL GMBH; COGAN, Derek; MOSS, Neil; SARKO, Christopher Ronald; BAMFORD, Samantha Jayne; LOKE, Pui Leng; NAPIER, Spencer Charles, R.; TYE, Heather; WHITTAKER, Mark Patent: WO2010/80357 A1, 2010 ; Location in patent: Page/Page column 45 ; WO 2010/080357 A1

142253-54-1

~81%

142253-55-2

Literature: PFIZER LIMITED; ACIRO, Caroline; BAGAL, Sharanjeet Kaur; HARVEY, John Wilson; JONES, Lyn Howard; MOWBRAY, Charles Eric; OWEN, Robert McKenzie; SABNIS, Yogesh Anil; STORER, Robert Ian; YEAP, Siew Kuen Patent: WO2010/131145 A1, 2010 ; Location in patent: Page/Page column 86 ;

7681-38-1

24424-99-5

36476-78-5

142253-55-2

Literature: US5977178 A1, ;

24424-99-5

142253-55-2

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 757 - 761

Precursor 5
24424-99-5 36476-78-5 102624-96-4 142253-54-1
7681-38-1
DownStream 10
610791-05-4 1025029-60-0 1001907-44-3 142253-56-3
254454-54-1 177947-96-5 820971-67-3 870089-49-9
887591-62-0 486415-29-6

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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