- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 1-Boc-azetidine-3-yl-methanol
- Price: ￥668.0/1g ￥258.0/250mg ￥1338.0/5g
- Purity: 97.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- Chengdu Pukang Biotechnology Co., Ltd.
- China
- Product Name: 1-Boc-azetidine-3-yl-methanol
- Price: ￥Inquiry/100kg
- Purity: 98.0%
- Stocking Period: 90 Day
- Contact: Lihua Yang
- DC Chemicals Limited
- China
- Product Name: 1-Boc-azetidine-3-yl-methanol
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 1-Boc-Azetidine-3-yl-methanol
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
142253-56-3
142253-56-3 structure
- Name: 1-Boc-azetidine-3-yl-methanol
- Chemical Name: 1-Boc-3-azetidinemethanol
- CAS Number: 142253-56-3
- Molecular Formula: C9H17NO3
- Molecular Weight: 187.236
- Catalog: Chemical reagent Organic reagent Imine, hydrazine
- Create Date: 2018-12-13 15:59:18
- Modify Date: 2024-01-02 07:17:52
-
1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]
| Name | 1-Boc-3-azetidinemethanol |
|---|---|
| Synonyms |
1-Boc-Azetidine-3-yl-methanol
tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate 3-(Hydroxymethyl)azetidine-1-carboxylate 1-(tert-Butoxycarbonyl)-3-azetidinemethanol 1-Boc-3-(hydroxymethyl)azetidine |
| Description | 1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 270.3±13.0 °C at 760 mmHg |
| Melting Point | 55 °C |
| Molecular Formula | C9H17NO3 |
| Molecular Weight | 187.236 |
| Flash Point | 117.3±19.8 °C |
| Exact Mass | 187.120850 |
| PSA | 49.77000 |
| LogP | 0.01 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.489 |
| Water Solubility | Soluble in Dimethyl sulfoxide (DMSO). |
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | 23-26-37-60 |
| HS Code | 2933990090 |
|
~98%
142253-56-3 |
| Literature: EP1961750 A1, ; Page/Page column 90 ; |
|
~99%
142253-56-3 |
| Literature: WO2013/83991 A1, ; Page/Page column 69-70 ; |
|
~%
142253-56-3 |
| Literature: US2010/261701 A1, ; Page/Page column 145 ; |
|
~74%
142253-56-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 51, # 4 p. 948 - 956 |
|
~%
142253-56-3 |
| Literature: WO2005/28474 A2, ; Page/Page column 219 ; WO 2005/028474 A2 |
|
~%
142253-56-3 |
| Literature: European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380 |
|
~%
142253-56-3 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 20 p. 5581 - 5585 |
| Precursor 7 | |
|---|---|
| DownStream 7 | |
![tert-butyl 3-[(methanesulfonyloxy)methyl]azetidine-1-carboxylate structure](https://www.chemsrc.com/caspic/265/142253-57-4.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |