1-Boc-azetidine-3-yl-methanol
1-Boc-azetidine-3-yl-methanol structure
|
Common Name | 1-Boc-azetidine-3-yl-methanol | ||
|---|---|---|---|---|
| CAS Number | 142253-56-3 | Molecular Weight | 187.236 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 270.3±13.0 °C at 760 mmHg | |
| Molecular Formula | C9H17NO3 | Melting Point | 55 °C | |
| MSDS | N/A | Flash Point | 117.3±19.8 °C | |
Use of 1-Boc-azetidine-3-yl-methanol1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] |
| Name | 1-Boc-3-azetidinemethanol |
|---|---|
| Synonym | More Synonyms |
| Description | 1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 270.3±13.0 °C at 760 mmHg |
| Melting Point | 55 °C |
| Molecular Formula | C9H17NO3 |
| Molecular Weight | 187.236 |
| Flash Point | 117.3±19.8 °C |
| Exact Mass | 187.120850 |
| PSA | 49.77000 |
| LogP | 0.01 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.489 |
| Water Solubility | Soluble in Dimethyl sulfoxide (DMSO). |
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | 23-26-37-60 |
| HS Code | 2933990090 |
|
~98%
1-Boc-azetidine... CAS#:142253-56-3 |
| Literature: EP1961750 A1, ; Page/Page column 90 ; |
|
~99%
1-Boc-azetidine... CAS#:142253-56-3 |
| Literature: WO2013/83991 A1, ; Page/Page column 69-70 ; |
|
~%
1-Boc-azetidine... CAS#:142253-56-3 |
| Literature: US2010/261701 A1, ; Page/Page column 145 ; |
|
~74%
1-Boc-azetidine... CAS#:142253-56-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 51, # 4 p. 948 - 956 |
|
~%
1-Boc-azetidine... CAS#:142253-56-3 |
| Literature: WO2005/28474 A2, ; Page/Page column 219 ; WO 2005/028474 A2 |
|
~%
1-Boc-azetidine... CAS#:142253-56-3 |
| Literature: European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380 |
|
~%
1-Boc-azetidine... CAS#:142253-56-3 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 20 p. 5581 - 5585 |
![[1-(Diphenylmethyl)-3-azetidinyl]methanol structure](https://image.chemsrc.com/caspic/408/72351-36-1.png)
| Precursor 7 | |
|---|---|
| DownStream 7 | |
![tert-butyl 3-[(methanesulfonyloxy)methyl]azetidine-1-carboxylate structure](https://image.chemsrc.com/caspic/265/142253-57-4.png)
CAS#:142253-57-4
CAS#:95849-02-8
CAS#:253176-94-2
CAS#:177947-96-5
CAS#:876589-20-7
CAS#:892408-42-3
CAS#:942308-05-6| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 1-Boc-Azetidine-3-yl-methanol |
| tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate |
| 3-(Hydroxymethyl)azetidine-1-carboxylate |
| 1-(tert-Butoxycarbonyl)-3-azetidinemethanol |
| 1-Boc-3-(hydroxymethyl)azetidine |
- Shanghai Nianxing Industrial Co., Ltd
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- Product Name: 1-Boc-azetidine-3-yl-methanol
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- China
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