1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER
Modify Date: 2024-01-05 13:44:23
1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER structure
|
Common Name | 1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER | ||
|---|---|---|---|---|
| CAS Number | 610791-05-4 | Molecular Weight | 215.246 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 269.0±33.0 °C at 760 mmHg | |
| Molecular Formula | C10H17NO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 116.5±25.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTERMethyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 |
| Name | Methyl 1-Boc-azetidine-3-carboxylate |
|---|---|
| Synonym | More Synonyms |
| Description | Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 269.0±33.0 °C at 760 mmHg |
| Molecular Formula | C10H17NO4 |
| Molecular Weight | 215.246 |
| Flash Point | 116.5±25.4 °C |
| Exact Mass | 215.115753 |
| PSA | 55.84000 |
| LogP | 0.73 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.481 |
|
~99%
1-BOC-AZETIDINE... CAS#:610791-05-4 |
| Literature: PFIZER INC. Patent: WO2006/21881 A2, 2006 ; Location in patent: Page/Page column 61 ; WO 2006/021881 A2 |
|
~98%
1-BOC-AZETIDINE... CAS#:610791-05-4 |
| Literature: AGOURON PHARMACEUTICALS, INC. Patent: US2006/46991 A1, 2006 ; Location in patent: Page/Page column 55-56 ; US 20060046991 A1 |
|
~14%
1-BOC-AZETIDINE... CAS#:610791-05-4 |
| Literature: Eisai RandD Management Co., Ltd. Patent: US2008/214815 A1, 2008 ; Location in patent: Page/Page column 15 ; |
| Precursor 5 | |
|---|---|
| DownStream 4 | |
CAS#:142253-56-3![tert-Butyl 8-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide structure](https://image.chemsrc.com/caspic/164/1340481-90-4.png)
CAS#:1340481-90-4![2-Methyl-2-propanyl 8-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carb oxylate structure](https://image.chemsrc.com/caspic/019/1340481-89-1.png)
CAS#:1340481-89-1
CAS#:1257293-79-0| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 1-O-tert-butyl 3-O-methyl azetidine-1,3-dicarboxylate |
| 1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER |