169675-09-6
169675-09-6 structure
- Name: Ro 60-0175 fumarate
- Chemical Name: Ro 60-0175 fumarate,(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanaminefumarate
- CAS Number: 169675-09-6
- Molecular Formula: C15H16ClFN2O4
- Molecular Weight: 342.75000
- Create Date: 2018-10-18 13:10:15
- Modify Date: 2024-01-05 14:52:28
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Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 fumarate reduces Cocaine self-administration, and the ability of Cocaine to reinstate responding after extinction of drug-seeking behavior[1].
| Name | Ro 60-0175 fumarate,(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanaminefumarate |
|---|---|
| Synonyms | ro 60-0175 fumarate |
| Description | Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 fumarate reduces Cocaine self-administration, and the ability of Cocaine to reinstate responding after extinction of drug-seeking behavior[1]. |
|---|---|
| Related Catalog | |
| Target |
5-HT2C Receptor |
| In Vivo | Ro60-0175 (1 mg/kg; s.c.) fumarate preserves the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reach their break-points earlier[1]. Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); s.c., i.p.) fumarate reduces responding for cocaine and effect is reversed by SB242084[1]. Ro60-0175 (0.3, 1, and 3 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) fumarate dose dependently attenuates the response increased by the yohimbine treatment alone relative to vehicle injection[1]. Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) fumarate reduces responding and that this effect is prevented by SB242084 pretreatment[1]. Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) fumarate significantly reduces responding on the active lever in the reinstatement group[1]. Ro60-0175 (0.5 mg/kg SB242084; 1 mg/kg Ro60-0175; s.c.; i.p.) fumarate reduces responding compared to vehicle in the reinstatement group, and that this effect is prevented by pretreatment with SB242084. For responding on the inactive lever, there are no significant main effects or interactions[1]. |
| References |
| Boiling Point | 353.2ºC at 760mmHg |
|---|---|
| Molecular Formula | C15H16ClFN2O4 |
| Molecular Weight | 342.75000 |
| Flash Point | 167.4ºC |
| Exact Mass | 342.07800 |
| PSA | 105.55000 |
| LogP | 3.19310 |
| Vapour Pressure | 3.65E-05mmHg at 25°C |