DC Chemicals Limited
China
Product Name: rac BHFF
Price: $400.0/100mg $720.0/250mg $1440.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

123557-91-5

123557-91-5 structure

Name: rac BHFF
Chemical Name: 5,7-ditert-butyl-3-hydroxy-3-(trifluoromethyl)-1-benzofuran-2-one
CAS Number: 123557-91-5
Molecular Formula: C₁₇H₂₁F₃O₃
Molecular Weight: 330.34
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2016-04-14 12:18:03
Modify Date: 2024-01-13 22:50:31
rac-BHFF is a potent and orally active allosteric enhancer of GABAB receptor[1].

Name	5,7-ditert-butyl-3-hydroxy-3-(trifluoromethyl)-1-benzofuran-2-one
Synonyms	bhff rac bhff

Description	rac-BHFF is a potent and orally active allosteric enhancer of GABAB receptor[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vivo	rac-BHFF has anxiolytic-like properties in stress-induced hyperthermia (SIH) in mice[1]. rac-BHFF (3, 10, 30 and 100 mg/kg, p.o.) reverses SIH and high significance was reached for 100 mg kg−1 (P<0.001)[1]. Animal Model: Male NMRI mice (20-25 g)[1]. Dosage: 3, 10, 30 or 100 mg/kg. Administration: P.O.. Result: Significantly increased the LRR effects of a subthreshold dose of baclofen at doses of 3 mg/kg and above.
References	[1]. P Malherbe, et al. Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br J Pharmacol. 2008 Jun;154(4):797-811.

Molecular Formula	C₁₇H₂₁F₃O₃
Molecular Weight	330.34
Exact Mass	330.14400
PSA	46.53000
LogP	3.95050
Storage condition	-20℃

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

13089-11-7

~64%

123557-91-5

Literature: Malherbe, Parichehr; Masciadri, Raffaello; Norcross, Roger David; Prinssen, Eric Patent: US2007/27204 A1, 2007 ; Location in patent: Page/Page column 8 ; US 20070027204 A1

13089-11-7

96-76-4

~99%

123557-91-5

Literature: Dyachenko, V. I.; Galakhov, M. V.; Kolomiets, A. F.; Fokin, A. V. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989 , vol. 38, # 4.2 p. 831 - 836 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989 , # 4 p. 923 - 928

Precursor 2
13089-11-7 96-76-4
DownStream 0

123557-91-5	125292-31-1
1073244-89-9	23155-00-2
1246814-56-1	641-92-9
3553-88-6	1076199-68-2
1048649-80-4	79541-43-8