189060-98-8

189060-98-8 structure

Name: NGB 2904
Chemical Name: NGB 2904,N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide
CAS Number: 189060-98-8
Molecular Formula: C₂₈H₃₀Cl₃N₃O
Molecular Weight: 530.91600
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2017-11-18 20:19:20
Modify Date: 2024-01-13 06:55:47
NGB 2904 is an orally active and selective dopamine (DA) D3 receptor antagonist. NGB 2904 can be used for the research of cocaine addiction[1].

Name	NGB 2904,N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide
Synonyms	NGB 2904 HYDROCHLORIDE Ngb-2904

Description	NGB 2904 is an orally active and selective dopamine (DA) D3 receptor antagonist. NGB 2904 can be used for the research of cocaine addiction[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D3 Receptor
In Vivo	NGB 2904 (0.1~5 mg/kg; i.p.) significantly loweres the break-point for cocaine self-administration behavior reinforced under progressive-ratio conditions and significantly inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats extinguished from daily cocaine self-administration[1]. NGB 2904 (0~10 mg/kg; i.p.) administered 30 min prior to the beginning of daily cocaine self-administration sessions has no significant effect on cocaine self-administration behavior at a unit cocaine reinforcement dose of 0.5 mg/kg/infusion compared to vehicle-treated animals. NGB 2904 (0.1 and 1 mg/kg) pretreatment significantly inhibits the enhanced brain stimulation reward produced by 2 mg/kg, but not by 10 mg/kg, of cocaine. NGB 2904 pretreatment produces a significant attenuation of this cocaine-triggered reinstatement of drug-seeking[1]. Animal Model: Male Long–Evans rats (250–300 g)[1] Dosage: 0.1~5 mg/kg Administration: I.p.; Result: Significantly lowered the break-point for cocaine self-administration behavior reinforced under progressive-ratio conditions and significantly inhibited cocaine-triggered reinstatement of drug-seeking behavior in rats extinguished from daily cocaine self-administration.
References	[1]. Xi ZX, et al. The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology. 2006;31(7):1393-1405.

Boiling Point	708.8ºC at 760 mmHg
Molecular Formula	C₂₈H₃₀Cl₃N₃O
Molecular Weight	530.91600
Flash Point	382.4ºC
Exact Mass	529.14500
PSA	35.58000
LogP	7.09260
Vapour Pressure	2.41E-20mmHg at 25°C

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