Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Sodium Aescinate
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Sodium Aescinate
Price: ￥118.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Sodium Aescinate
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sodium escinate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Escin, monosodium salt
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

20977-05-3

20977-05-3 structure

Name: Sodium Aescinate
Chemical Name: Escin monosodium salt
CAS Number: 20977-05-3
Molecular Formula: C₅₄H₈₃NaO₂₃
Molecular Weight: 1124.2202
Catalog: API Circulatory system medication Other circulatory system medication
Create Date: 2018-06-29 14:41:03
Modify Date: 2024-01-02 12:16:14
Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities[1]. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway[2].

Name	Escin monosodium salt
Synonyms	3-methyl-pyridine-2-carbonitrile 3-methyl-2-pyridinecarbonitrile 2-cyano-3-methly pyridine 2-cyano-b-picoline 3-methylpyridine-2-carbonitrile 2-Cyano-3-methylpyridine (h4tes4)[qr] akrochem tdec diethyl-carbamodithioicacitetrakis(anhydrosulfide)withthiotelluricac Sodium escinate

Description	Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities[1]. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Sodium aescinate can block signals transiting to downstream molecules AKT, ERK, inhibit the proliferation of breast cancer cell MCF-7 cell apoptosis and induced cell apoptosis by suppressing the activation of SRC[3].
In Vivo	Sodium aescinate may effectively controls and improves wound healing in diabetic rats via its anti-inflammatory and antioxidant activities[1]. Sodium aescinate treatment can alleviate the symptom of polycystic ovary syndrome (PCOS) in rat model through regulating the PI3K/Akt/GSK3-β pathway[4].
References	[1]. Zhang Z, et al. The Efficacy of Sodium Aescinate on Cutaneous Wound Healing in Diabetic Rats. Inflammation. 2015 Oct;38(5):1942-8. [2]. Hou H, et al. CARMA3/NF-κB signaling contributes to tumorigenesis of hepatocellular carcinoma and is inhibited by sodium aescinate. World J Gastroenterol. 2019 Sep 28;25(36):5483-5493. [3]. Qi SM, et al. Effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis by inhibiting AKT, ERK and upstream signal SRC activity. Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(16):3267-72. [4]. Chen L, et al. Effect of sodium aescinate treatment on PCOS rat model with insulin resistance. Bratisl Lek Listy. 2017;118(4):223-227.

Molecular Formula	C₅₄H₈₃NaO₂₃
Molecular Weight	1124.2202

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