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9004-65-3

9004-65-3 structure
9004-65-3 structure
Name Hypromellose
Synonyms 2-Hydroxypropyl 2,3,6-tris-O-(2-hydroxypropyl)-4-O-[2,3,4,6-tetrakis-O-(2-hydroxypropyl)-β-D-glucopyranosyl]-β-D-glucopyranoside - methyl 2,3,6-tri-O-methyl-4-O-(2,3,4,6-tetra-O-methyl-β-D-gl ucopyranosyl)-β-D-glucopyranoside (1:1)
Hydroxypropyl methyl cellulose
EINECS 220-971-6
MHPC
Hydroxypropyl methylcellulose
MFCD00131360
E464
β-D-Glucopyranoside, 2-hydroxypropyl 2,3,6-tris-O-(2-hydroxypropyl)-4-O-[2,3,4,6-tetrakis-O-(2-hydroxypropyl)-β-D-glucopyranosyl]-, compd. with β-D-glucopyranoside, methyl 2,3,6-tri-O-methyl- 4-O-(2,3,4,6-tetra-O-methyl-β-D-glucopyranosyl)- (1:1)
HPMC
Description Hypromellose is a water-soluble hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices.
Related Catalog
In Vitro Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect[1]. Hypromellose (hydroxypropylmethylcellulose) has been used in sustained-release pharmaceutical products for many years. When used in matrix tablets, these polymers hydrate on contact with water to produce a viscous gel barrier within and surrounding the tablet. The properties of hypromellose that affect the rate of drug release include the rate of diffusion of water into the dry polymer, the rate of hypromellose hydration and gel formation, the viscosity of the hydrated hypromellose and rate of hypromellose gel erosion[2].
In Vivo Punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye. Fluorescein and rose bengal staining tests show that there was a significant reduction in signs after occlusion using hypromellose[3]. Hypromellose is effective in improving the blood glucose metabolism and suppressing oxidative stress in mice fed with a high fat diet. The antihyperglycemic and antioxidative effects of hypromellose could be partly attributed to the regulation of hepatic glucose-regulating enzyme activities and activation of the hepatic and erythrocyte antioxidant enzymes. Hypromellose may be useful as biomaterials in the development of functional food or as therapeutic agents against high fat-induced hyperglycemia and oxidative stress[4].
References

[1]. Li CL, et al. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005 May;57(5):533-46.

[2]. Braund R, et al. Hypromellose films for the delivery of growth factors for wound healing.

[3]. Capita L, et al. Prospective evaluation of hypromellose 2% for punctal occlusion in patients with dry eye. Cornea. 2015 Feb;34(2):188-92.

[4]. Ban SJ, et al. Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet. Int J Mol Sci. 2012;13(3):3738-50.
Density 1.39
Molecular Formula C18H38O14
Molecular Weight 478.49
Appearance powder
Stability Stable. Solid is combustible, incompatible with strong oxidizing agents.
Water Solubility H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow | SOLUBLE
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS NF9125000

Chemsrc provides CAS#:9004-65-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 9004-65-3 | Chemsrc address: https://www.chemsrc.com/en/baike/121194.html

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