892489-52-0

892489-52-0 structure

Name: AZD 3988
Chemical Name: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
CAS Number: 892489-52-0
Molecular Formula: C₂₃H₂₂F₂N₄O₄
Molecular Weight: 456.44
Catalog: Signaling Pathways Metabolic Enzyme/Protease Acyltransferase
Create Date: 2018-12-27 18:46:42
Modify Date: 2024-01-11 15:05:04
AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively[1].

Name	trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
Synonyms	2H-Cyclopenta[b]furan-2-one,hexahydro-6-hydroxy (trans-4-{4-[({5-[(3,4-difluorophenyl)amino]-1,3,4-oxadiazol-2-yl}carbonyl)amino]phenyl}cyclohexyl)acetic acid 6-Hydroxyhexahydrocyclopenta[b]furan-2-one (trans-2,3-Dihydroxy-cyclopentyl)-essigsaeure-lacton

Description	AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase
Target	IC50: 6 nM (h DGAT-1), 5 nM (Rat DGAT-1), 11 nM (Mouse DGAT-1)[1]
References	[1]. McCoull W, et al. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8.

892489-51-9

~80%

892489-52-0

Literature: ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2007/144571 A1, 2007 ; Location in patent: Page/Page column 21-22 ; WO 2007/144571 A1