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1334298-90-6

1334298-90-6 structure
1334298-90-6 structure
  • Name: Itacitinib
  • Chemical Name: incb-039110
  • CAS Number: 1334298-90-6
  • Molecular Formula: C26H23F4N9O
  • Molecular Weight: 553.51400
  • Catalog: Signaling Pathways Epigenetics JAK
  • Create Date: 2018-02-12 20:23:43
  • Modify Date: 2024-01-08 15:34:36
  • Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.

Name incb-039110
Synonyms 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile
{1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile
{1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin3-yl}acetonitrile
Itacitinib
Description Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.
Related Catalog
Target

JAK1

In Vitro Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis[1].
References

[1]. Mascarenhas JO, et al. Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis. Haematologica. 2017 Feb;102(2):327-335.

Density 1.57±0.1 g/cm3(Predicted)
Molecular Formula C26H23F4N9O
Molecular Weight 553.51400
Exact Mass 553.19600
PSA 119.62000
LogP 3.47948
Storage condition -20℃
Hazard Codes N