431996-53-1

431996-53-1 structure

Name: Filastatin
Chemical Name: (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone
CAS Number: 431996-53-1
Molecular Formula: C₁₈H₁₈ClN₃O₃
Molecular Weight: 359.80700
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-01-17 07:12:27
Modify Date: 2024-01-12 18:19:44
Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect[1].

Name	(3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone
Synonyms	Filastatin

Description	Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
References	[1]. Ahmed Fazly, et al. Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13594-9.