Filastatin

Modify Date: 2024-01-12 18:19:44

Filastatin structure	Common Name	Filastatin
	CAS Number	431996-53-1	Molecular Weight	359.80700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₈ClN₃O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Filastatin

Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect[1].

Name	(3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone
Synonym	More Synonyms

Description	Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
References	[1]. Ahmed Fazly, et al. Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13594-9.

Molecular Formula	C₁₈H₁₈ClN₃O₃
Molecular Weight	359.80700
Exact Mass	359.10400
PSA	69.37000
LogP	4.04510

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H315-H319-H335-H410
Precautionary Statements	P261-P273-P305 + P351 + P338-P501
Hazard Codes	Xi
RIDADR	UN 3077 9 / PGIII