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  • DC Chemicals Limited
  • China
  • Product Name: Tolazoline
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

59-98-3

59-98-3 structure
59-98-3 structure
  • Name: tolazoline
  • Chemical Name: tolazoline
  • CAS Number: 59-98-3
  • Molecular Formula: C10H12N2
  • Molecular Weight: 160.216
  • Catalog: API Circulatory system medication Peripheral vasodilator
  • Create Date: 2018-07-24 16:44:56
  • Modify Date: 2024-01-05 17:18:18
  • Tolazoline(NSC35110; Imidaline) is a non-selective competitive α-adrenergic receptor antagonist.IC50 value:Target: α-adrenoceptor antagonistTolazoline can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product. The structure of tolazoline is strikingly similar to α-adrenergic agonists, which are antiedema sympathomimetics.

Name tolazoline
Synonyms Benzidazol
Tolazolin
2-benzyl-4,5-diyhdroimidazole
2-Benzyl-4,5-dihydro-1H-imidazole
Priscol
EINECS 200-448-9
2-(phenylmethyl)-4,5-dihydro-1H-imidazole
Prefaxil
1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-
2-benzyl-2-imidazoline
tolazoline
Imidalin
MFCD00005182
2-Benzyl-4,5-dihydroimidazole
Divascol
2-Benzylimidazoline
Olitensol
Priscoline
Description Tolazoline(NSC35110; Imidaline) is a non-selective competitive α-adrenergic receptor antagonist.IC50 value:Target: α-adrenoceptor antagonistTolazoline can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product. The structure of tolazoline is strikingly similar to α-adrenergic agonists, which are antiedema sympathomimetics.
Related Catalog
References

[1]. Tolazoline, From Wikipedia

Density 1.1±0.1 g/cm3
Boiling Point 338.2±21.0 °C at 760 mmHg
Melting Point 66-69 °C(lit.)
Molecular Formula C10H12N2
Molecular Weight 160.216
Flash Point 158.3±22.1 °C
Exact Mass 160.100052
PSA 24.39000
LogP 2.65
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.596

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ1925000
CHEMICAL NAME :
2-Imidazoline, 2-benzyl-
CAS REGISTRY NUMBER :
59-98-3
BEILSTEIN REFERENCE NO. :
0128757
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C10-H12-N2
MOLECULAR WEIGHT :
160.24
WISWESSER LINE NOTATION :
T5M CN BUTJ B1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
62500 ug/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22;R36/37/38
Safety Phrases S26-S28-S36/37/39-S45
WGK Germany 3
RTECS NJ1925000
HS Code 2933290090
HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%