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Product Name: Beclobrate
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55937-99-0

55937-99-0 structure

55937-99-0 structure

Name: Beclobrate
Chemical Name: Beclobrate
CAS Number: 55937-99-0
Molecular Formula: C₂₀H₂₃ClO₃
Molecular Weight: 346.84800
Catalog: API Circulatory system medication Regulating blood lipids
Create Date: 2018-02-28 08:00:00
Modify Date: 2024-01-08 11:20:59
Beclobrate (Sgd 24774), a Fibric acid derivative, displays remarkable lipid lowering activity in rodents[1].

Name	Beclobrate
Synonyms	Turec Beclipur Beclofibrat

Description	Beclobrate (Sgd 24774), a Fibric acid derivative, displays remarkable lipid lowering activity in rodents[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vivo	On the normal diet rats, Beclobrate lowers total plasma cholesterol by 22-33.4% (10-50 mg/kg); the cholesterol reduction occurred mainly in high density lipoproteins (HDL). In addition, Beclobrate administration dramatically increases the activity of the high-affinity receptors for beta-VLDL in isolated liver membranes[1].
References	[1]. C Manzoni, et al. Differential effects of beclobrate on lipid/lipoprotein distribution in normal and hypercholesterolemic rats. Eur J Pharmacol. 1990 Nov 6;190(1-2):39-49.

Density	1.128g/cm3
Boiling Point	437.5ºC at 760mmHg
Molecular Formula	C₂₀H₂₃ClO₃
Molecular Weight	346.84800
Flash Point	149.6ºC
Exact Mass	346.13400
PSA	35.53000
LogP	5.04140
Index of Refraction	1.541
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7761040

CHEMICAL NAME :: Butanoic acid, 2-(4-((4-chlorophenyl)methyl)phenoxy)-2-methyl-, ethyl ester, (+-)-

CAS REGISTRY NUMBER :: 55937-99-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H23-Cl-O3

MOLECULAR WEIGHT :: 346.88

WISWESSER LINE NOTATION :: GR D1R DOX2&1&VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 5,237,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4214095

HS Code	2918990090

5398-71-0 structure

5398-71-0

52890-73-0 structure

52890-73-0

~%

55937-99-0 structure

55937-99-0

Literature: Arzneimittel-Forschung, , vol. 29, # 5 p. 711 - 720

64-17-5 structure

64-17-5

67-66-3 structure

67-66-3

52890-73-0 structure

52890-73-0

78-93-3 structure

78-93-3

~%

Detail

Literature: Arzneimittel-Forschung, , vol. 29, # 5 p. 711 - 720

Precursor 5
5398-71-0 52890-73-0 64-17-5 67-66-3
78-93-3
DownStream 3
71548-88-4 71548-95-3 71548-99-7

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%