1128086-25-8

1128086-25-8 structure

Name: Donepezil-d5
Chemical Name: 5,6-dimethoxy-2-((1-((phenyl-d5)methyl)piperidin-4-yl)methyl)-2,3-dihydro-1H-inden-1-one
CAS Number: 1128086-25-8
Molecular Formula: C₂₄H₂₄D₅NO₃
Molecular Weight: 384.52
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2018-02-08 03:40:19
Modify Date: 2024-02-04 16:42:25
Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

Name	5,6-dimethoxy-2-((1-((phenyl-d5)methyl)piperidin-4-yl)methyl)-2,3-dihydro-1H-inden-1-one

Description	Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13. [3]. Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38(1): p. 181-93. [4]. Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18(2): p. 185-7.