62488-57-7

62488-57-7 structure

Name: Dihydro-5-azacytidine
Chemical Name: 5,6-Dihydro-5-azacytidine
CAS Number: 62488-57-7
Molecular Formula: C₈H₁₄N₄O₅
Molecular Weight: 246.221
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2016-12-11 00:03:17
Modify Date: 2024-01-16 11:55:57
Dihydro-5-azacytidine (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine has an antitumor activity[1][2].

Name	5,6-Dihydro-5-azacytidine
Synonyms	1,3,5-triazin-2(1H)-one, 4-amino-5,6-dihydro-1-β-D-ribofuranosyl- 4-Amino-1-(β-D-ribofuranosyl)-5,6-dihydro-1,3,5-triazin-2(1H)-one 5,6 dihydro-5-azacytidine 1,3,5-Triazin-2(1H)-one, 4-amino-3,6-dihydro-1-β-D-ribofuranosyl- 6-Amino-3-(β-D-ribofuranosyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one

Description	Dihydro-5-azacytidine (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine has an antitumor activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Signaling Pathways >> Epigenetics >> DNA Methyltransferase
In Vitro	Methylation studies show that an LD10 dose of [3H]DHAC results in a 25.06% hypomethylation of DNA in L1210/0 cells and a 46.32% hypomethylation in a deoxycytidine kinase mutant cell line L1210/dCK(-), compared with their respective controls[2]. Dihydro-5-azacytidine (DHAC) competes with cytidine triphosphate for incorporation into RNA, leading to ribosomal degradation and defective protein synthesis[1].
In Vivo	In tumor-bearing mice (injected with L1210/0 cells), after an LD10 dose of Dihydro-5-azacytidine (DHAC; 1500 mg/kg), the plasma peak concentration achieved is 317 μM and is eliminated biexponentially, with a t1/2 α of 1.03 h and a t1/2 β of 5 h[2].
References	[1]. Robert A Kratzke, et al. Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. J Thorac Oncol. 2008 Apr;3(4):417-21. [2]. W C Powell, et al. Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210)-bearing mice. Cancer Chemother Pharmacol. 1988;21(2):117-21.

CHEMICAL NAME :: s-Triazin-2(1H)-one, 5,6-dihydro-4-amino-1-beta-D-ribofuranosyl-

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,817,1982