1224606-06-7
1224606-06-7 structure
- Name: D-Lin-MC3-DMA
- Chemical Name: DLin-M-C3-DMA
- CAS Number: 1224606-06-7
- Molecular Formula: C43H79NO2
- Molecular Weight: 642.09300
- Catalog: Research Areas Cancer
- Create Date: 2018-06-01 12:05:52
- Modify Date: 2024-01-04 17:47:34
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D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
| Name | DLin-M-C3-DMA |
|---|---|
| Synonyms |
(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
(6Z,9Z,28Z,31Z)-heptatriaonta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate dilinoleylmethyl 4-(dimethylamino)butanoate (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate (6Z,9Z,28Z,31Z)heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate D-Lin-MC3-DMA |
| Description | D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle. |
|---|---|
| Related Catalog | |
| In Vivo | Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pKa value that leads to dramatically enhanced potency[1]. |
| References |
| Density | 0.886±0.06 g/cm3(Predicted) |
|---|---|
| Boiling Point | 670.2±43.0 °C(Predicted) |
| Molecular Formula | C43H79NO2 |
| Molecular Weight | 642.09300 |
| Exact Mass | 641.61100 |
| PSA | 29.54000 |
| LogP | 13.64720 |
| Storage condition | -20℃ |