63932-07-0

63932-07-0 structure

Name: Anti-inflammatory agent 11
Chemical Name: N4-benzyl-iso-nicotinic acid thio-semicarbazide
CAS Number: 63932-07-0
Molecular Formula: C₁₄H₁₄N₄OS
Molecular Weight: 286.35
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-04-12 13:02:29
Modify Date: 2024-03-03 16:11:45
Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1].

Name	N4-benzyl-iso-nicotinic acid thio-semicarbazide
Synonyms	4-benzyl-1-(4-pyridylcarbonyl)thiosemicarbazide 4-benzyl-1-isonicotinoyl-thiosemicarbazide 4-benzyl-1-(4-pyridoyl) thiosemicarbazide

Description	Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	TNF-α
In Vitro	Anti-inflammatory agent 11 (compound 16) is active in the reduction of accumulated nitrite, with an IC50 of 64.8 ± 1.0 μM[1].
References	[1]. Calixto SD, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506.