134179-44-5

134179-44-5 structure

Name: Phthalamide-PEG3-azide
Chemical Name: 1-azido-11-phthalimido-3,6,9-trioxaundecane
CAS Number: 134179-44-5
Molecular Formula: C₁₆H₂₀N₄O₅
Molecular Weight: 348.35400
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-03-03 12:11:43
Modify Date: 2024-07-17 10:17:16
Phthalamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-azido-11-phthalimido-3,6,9-trioxaundecane
Synonyms	2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethyl)-isoindole-1,3-dione

Description	Phthalamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562