1208123-85-6

1208123-85-6 structure

Name: CaMKII-IN-1
Chemical Name: N-{6-Benzyl-2-[(2-phenylethyl)amino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl}-3-chloro-2-methylbenzenesulfonamide
CAS Number: 1208123-85-6
Molecular Formula: C₂₉H₃₀ClN₅O₂S
Molecular Weight: 548.09900
Catalog: Signaling Pathways Neuronal Signaling CaMK
Create Date: 2018-04-04 10:25:42
Modify Date: 2024-01-07 21:44:47
CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.IC50 value: 63 nMTarget: CaMKII

Name	N-{6-Benzyl-2-[(2-phenylethyl)amino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl}-3-chloro-2-methylbenzenesulfonamide
Synonyms	N-{6-Benzyl-2-[(2-phenylethyl)amino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl}-3-chloro-2-methylbenzenesulfonamide Benzenesulfonamide, 3-chloro-2-methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)amino]-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4-yl]- CaMKII-IN-1

Description	CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.IC50 value: 63 nMTarget: CaMKII
Related Catalog	Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Inflammation/Immunology
References	[1]. Asano S, et al. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6696-8.