107220-29-1

107220-29-1 structure

Name: AF 102A hydrochloride
Chemical Name: (2R)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane],hydrochloride
CAS Number: 107220-29-1
Molecular Formula: C₁₀H₁₈ClNOS
Molecular Weight: 235.77400
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2017-09-07 10:35:33
Modify Date: 2024-01-13 18:12:07
Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease[1].

Name	(2R)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane],hydrochloride
Synonyms	AF 102A HCl trans-Cevimeline Hydrochloride AF 102A hydrochloride

Description	Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	M1[1]
In Vivo	AF102A (1 mg/kg; i.p.) reverses cognitive impairments in a step-through passive avoidance task[1]. Animal Model: Rats[1] Dosage: 1 mg/kg Administration: I.p. Result: Reversed cognitive impairments in a step-through passive avoidance task.
References	[1]. Fisher A, et al. (+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J Pharmacol Exp Ther. 1991;257(1):392-403.