167173-85-5

167173-85-5 structure

Name: UK-2A
Chemical Name: (3S,6S,7R,8R)-8-benzyl-3-{[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]amino}-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl2-methylpropanoate
CAS Number: 167173-85-5
Molecular Formula: C₂₆H₃₀N₂O₉
Molecular Weight: 514.52400
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-03-21 00:20:14
Modify Date: 2024-01-02 22:40:21
UK-2A (Antibiotic UK 2A) is a potent antifungal antibiotic. UK-2A shows antifungal activity[1][2].

Name	(3S,6S,7R,8R)-8-benzyl-3-{[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]amino}-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl2-methylpropanoate
Synonyms	UK-2A (3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl isobutyrate Isobutyric acid (3S,6S,7R,8R)-8-benzyl-3-[(3-hydroxy-4-methoxy-pyridine-2-carbonyl)-amino]-6-methyl-4,9-dioxo-[1,5]dioxonan-7-yl ester (3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-di-oxonan-7-yl isobutyrate

Description	UK-2A (Antibiotic UK 2A) is a potent antifungal antibiotic. UK-2A shows antifungal activity[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	UK-2A (0-100 µg/mL; 24, 48, 120 h) 显示出针抗真菌活性，对 R. mucilaginosa IFO 0001 在 24、48、120 小时的 MIC 值分别为 1.56、>100、>100 µg/mL[2]。
References	[1]. Ueki M, et al. UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties. J Antibiot (Tokyo). 1996 Jul;49(7):639-43. [2]. Tani K, et al. UK-2A, B, C, and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VII. Membrane injury induced by C9-UK-2A, a derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001. J Antibiot (Tokyo). 2002 Mar;55(3):315-21.