1017606-66-4

1017606-66-4 structure

Name: LPA2 antagonist 1
Chemical Name: N-[(2S)-1-{4-[(3,4-Dichlorophenyl)sulfonyl]-1-piperazinyl}-2-propanyl]-7-methylthieno[3,2-d]pyrimidin-4-amine
CAS Number: 1017606-66-4
Molecular Formula: C₂₀H₂₃Cl₂N₅O₂S₂
Molecular Weight: 500.465
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2018-03-21 15:04:49
Modify Date: 2024-01-08 14:25:11
LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.

Name	N-[(2S)-1-{4-[(3,4-Dichlorophenyl)sulfonyl]-1-piperazinyl}-2-propanyl]-7-methylthieno[3,2-d]pyrimidin-4-amine
Synonyms	N-[(2S)-1-{4-[(3,4-Dichlorophenyl)sulfonyl]-1-piperazinyl}-2-propanyl]-7-methylthieno[3,2-d]pyrimidin-4-amine N-[(2S)-1-{4-[(3,4-dichlorophenyl)sulfonyl]piperazin-1-yl}propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine thieno[3,2-d]pyrimidin-4-amine, N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-methylethyl]-7-methyl- LPA2 antagonist 1

Description	LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Cancer
Target	IC50: 17 nM (LPA2)[1]
In Vitro	LPA2 antagonist 1 inhibits the phosphorylation of Erk induced by LPA in a concentration dependent manner. LPA2 antagonist 1 inhibits HCT-116 colon cancer cell proliferation caused by LPA in a doses dependent manner[1].
References	[1]. Beck HP, et al. Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41.