204395-52-8

204395-52-8 structure
204395-52-8 structure
  • Name: Clozapine-d4
  • Chemical Name: 8-Chloro-11-[4-methyl(2,2,6,6-2H4)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine
  • CAS Number: 204395-52-8
  • Molecular Formula: C18H15D4ClN4
  • Molecular Weight: 330.848
  • Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
  • Create Date: 2018-06-12 14:22:59
  • Modify Date: 2024-01-03 12:21:39
  • Clozapine-d4 (HF 1854-d4) is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5].

Name 8-Chloro-11-[4-methyl(2,2,6,6-2H4)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine
Synonyms 8-Chloro-11-[4-methyl(2,2,6,6-H)piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl-2,2,6,6-d)-
8-Chloro-11-[4-methyl(2,2,6,6-H)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine
Description Clozapine-d4 (HF 1854-d4) is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9.

[3]. Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288(3):236-40.

[4]. Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan;225(1):217-26.

[5]. Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269(3):R1-2.

Density 1.3±0.1 g/cm3
Boiling Point 489.2±55.0 °C at 760 mmHg
Molecular Formula C18H15D4ClN4
Molecular Weight 330.848
Flash Point 249.6±31.5 °C
Exact Mass 330.154938
LogP 2.36
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.681
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution