Name | 8-Chloro-11-[4-methyl(2,2,6,6-2H4)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine |
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Synonyms |
8-Chloro-11-[4-methyl(2,2,6,6-H)piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl-2,2,6,6-d)- 8-Chloro-11-[4-methyl(2,2,6,6-H)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine |
Description | Clozapine-d4 (HF 1854-d4) is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5]. |
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Related Catalog | |
In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
References |
[2]. Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 489.2±55.0 °C at 760 mmHg |
Molecular Formula | C18H15D4ClN4 |
Molecular Weight | 330.848 |
Flash Point | 249.6±31.5 °C |
Exact Mass | 330.154938 |
LogP | 2.36 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.681 |
Symbol |
GHS02, GHS06, GHS08 |
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Signal Word | Danger |
Hazard Statements | H225-H301 + H311 + H331-H370 |
Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |