509148-73-6

509148-73-6 structure

Name: NH2-C2-NH-Boc-d4
Chemical Name: tert-Butyl [2-amino(2H4)ethyl]carbamate
CAS Number: 509148-73-6
Molecular Formula: C₇H₁₂D₄N₂O₂
Molecular Weight: 164.239
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-04-22 01:28:01
Modify Date: 2024-01-03 22:22:16
NH2-C2-NH-Boc-d4 is the deuterium labeled NH2-C2-NH-Boc[1]. NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[2].

Name	tert-Butyl [2-amino(2H4)ethyl]carbamate
Synonyms	tert-Butyl [2-amino(H)ethyl]carbamate Carbamic acid, N-(2-aminoethyl-1,1,2,2-d)-, 1,1-dimethylethyl ester 2-Methyl-2-propanyl [2-amino(H)ethyl]carbamate

Description	NH2-C2-NH-Boc-d4 is the deuterium labeled NH2-C2-NH-Boc[1]. NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.