NH2-C2-NH-Boc-d4

Modify Date: 2024-01-03 22:22:16

NH2-C2-NH-Boc-d4 Structure
NH2-C2-NH-Boc-d4 structure
Common Name NH2-C2-NH-Boc-d4
CAS Number 509148-73-6 Molecular Weight 164.239
Density 1.0±0.1 g/cm3 Boiling Point 252.8±23.0 °C at 760 mmHg
Molecular Formula C7H12D4N2O2 Melting Point N/A
MSDS N/A Flash Point 106.7±22.6 °C

 Use of NH2-C2-NH-Boc-d4


NH2-C2-NH-Boc-d4 is the deuterium labeled NH2-C2-NH-Boc[1]. NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[2].

 Names

Name tert-Butyl [2-amino(2H4)ethyl]carbamate
Synonym More Synonyms

 NH2-C2-NH-Boc-d4 Biological Activity

Description NH2-C2-NH-Boc-d4 is the deuterium labeled NH2-C2-NH-Boc[1]. NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 252.8±23.0 °C at 760 mmHg
Molecular Formula C7H12D4N2O2
Molecular Weight 164.239
Flash Point 106.7±22.6 °C
Exact Mass 164.146286
LogP 0.54
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.454

 Synonyms

tert-Butyl [2-amino(H)ethyl]carbamate
Carbamic acid, N-(2-aminoethyl-1,1,2,2-d)-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl [2-amino(H)ethyl]carbamate